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Is Contrave the Answer to Obesity?

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Are diet pills the answer to the obesity epidemic? The simple answer is ... NO. However, it is a little more complicated than that. I've written a lot about diet pills and how bad I think they are, especially when they are sold over the counter and without doctor supervision. But there is something new, and it could be approved by the FDA as early as January. It's called Contrave, and it's a weight-loss pill that combines an anti-depressant medication with an anti-addiction medication.

According to the story on Yahoo! news,

Contrave is a combination of two well-known drugs, naltrexone (Revia , used to fight addictions) and the antidepressant bupropion (known by a number of names, including Wellbutrin). The drug appears to boost weight loss by changing the workings of the body's central nervous system, the researchers said.

One of the benefits of this drug is that it's not a stimulant. This is from Suite 101 -- Is The New Diet Pill Really Safe?

Diet pills are usually amphetamines (stimulants). They are made to speed up your whole body and therefore your metabolism. Most diet pills are taken off the market within five years of FDA approval. Almost all of them are taken off the market for the same reason, increased heart risks.

Contrave does not work as a stimulant; instead, it is a medication that helps an obese patient with appetite control, and would need to be accompanied by a healthy diet in order for the patient to see any results. It's not a quick fix or a miracle drug, and it's not without side effects. This is from The New York Times - FDA Panel's Backs New Diet Pill:

With Contrave , the big issue was that the drug had only modest effectiveness while also causing a slight increase in blood pressure and pulse rate. That could conceivably raise the risk of heart attacks and strokes, though the trials conducted by Orexigen were too small and too short to determine that.

Both the F.D.A. and the company said that a larger trial to look specifically at risk of heart attacks and other cardiovascular problems would be conducted.

For me, even if this drug is approved by the FDA, the jury is still out on whether or not the benefits outweigh the risks. But I do think Contrave has the potential for success, and this is why...

1. It's not over the counter, and patients would definitely need to be under the care and supervision of a doctor when using this medication.

2. The drug needs to be used in conjunction with a healthy diet, and in the long run the patient may achieve healthier eating habits that they can stick to.

3. The weight loss would be gradual, which usually means there is a greater chance for keeping it off.

4. Because it does include an anti-depressant medication, it may also help to curb "emotional" eating.

5. Most important, it could help the patient avoid the deadly complications of obesity (such as diabetes and heart disease).

It may just be wishful thinking on my part, but overall I'm hopeful about this new weight-loss medication, mostly because I want there to be something that can help. I know that obesity isn't a problem that can be solved with one pill, but if a pill could help, I think that would be a good thing.

This is a video I came across that helps explain the risks and benefits of diet pills.

What do you think? Would you like to see a weight-loss pill like Contrave be approved by the FDA? If your health were in jeopardy due to obesity, would you find a pill like this helpful? Are the benefits worth the risk? Is it a drawback that Contrave isn't a quick fix? Let us know what you think in comments.

Contributing Editor Catherine Morgan
Also at Catherine-Morgan.com

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Ladyjwanderlust 7 pts

Thanks for posting this. I had never heard  of Contrave and honestly, I think if I hadn't been able to lose my first 20 pounds and feel motivated I would have definitely tried a drug like this. I like that fact that at least there are alternatives to diet pills so people don't suck down Zantrex (I have, it made me miserable and jittery.) Addiction and depression are powerful-- I wouldn't judge others for giving a regimen like this a try. Great find.

Catherine Morgan 5 pts

I totally agree...Although I don't think this post is providing "false" hope (at least that wasn't my intention). I do think feeling hopeful that we may find success is a good thing, it may be what encourages us to try and make the healthy changes necessary.

Thanks for your comment.
:-)

Contributing Editor Catherine Morgan
Also at Catherine-Morgan.com ( http://catherine-morgan.com/ )

Catherine Morgan 5 pts

I love how you point out that the new drug has "con" in the name...probably not the best name.
;-)

Contributing Editor Catherine Morgan
Also at Catherine-Morgan.com ( http://catherine-morgan.com/ )

Catherine Morgan 5 pts

I agree, Melissa...Hopefully when doctors perscribe these medications they are taking the time to educate patients in healthy eating and explain that it's not a quick fix.

Contributing Editor Catherine Morgan
Also at Catherine-Morgan.com ( http://catherine-morgan.com/ )

Catherine Morgan 5 pts

I agree, even if a pill is helpful, success really is in lifestyle and healthy eating changes.

Thanks for commenting.

Contributing Editor Catherine Morgan
Also at Catherine-Morgan.com ( http://catherine-morgan.com/ )

RobynsWorld 5 pts

As a fat person myself I think that sometimes doctors convince patients to try something for weight loss that truly may increase other risks - but look at the warning for just about any medication out there and the side effects of it. Being morbidly obese you already run a huge risk for heart attacks and strokes, so do you do nothing and maintain that risk factor or do you try and do something that will temporarily raise your risks but also help you more quickly lose the other risks factors you have from the increased weight? I think only a person and their doctor can really make the right decision for them. For me personally, even though there are different pills and surgeries available, I think I just have to get to the point where I will go the route of diet and exercise because that is honestly what I need to do.

Robyn's Online World

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MariaD 5 pts

How does the anti-depressant work? Most psych meds cause weight gain due to water retention and/or sugar cravings.

For people with a few pounds to lose, this might be okay. But for people with a lot of weight to lose and more complex issues surrounding food, this may be just another failed diet experiment.

MD

http://mariadiaz.tumblr.com // http://bravogossip.com 

ModaMama 6 pts

I do find it particularly interesting that this pill specifically addresses additional concerns which may contribute to weight loss. Maybe this is a good place to bring patients into the doctor to say "I'm over-weight and depressed and looking for a long term plan."

Addressing concerns of patients running and demanding a specific medication, it is a health care practitioner's responsibility to help determine treatment based on their expertise and not to push drugs because a patient saw the add on TV (marketing pharmaceuticals to the public is illegal in many countries for this very reason). Any ethical MD should clearly look at a patient and say, this is not an answer/option/choice for you for reasons XYZ. That's their job.

Perhaps this new drug can be looked at as a possible component to a multi-faceted (problem) answer. Thanks for posting.

www.SaraInAkko.blogspot.com ( http://www.SaraInAkko.blogspot.com )

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Gena Haskett 40 pts

I have great concerns about this product. I've seen so many pills introduced for weight control only to find out three years later that it causes death or injury.

There would be a class of folks that should not take this pill; if you already suffer from high blood pressure I can't imagine a doctor would proscribe this pill to increase your BP so that you can lose weight.

The anti-depressant thing also concerns me. Have folks checks out the possible side effects?

If you experience any of the following symptoms, stop taking bupropion (Zyban aka Wellbutrin) and call your doctor immediately: suicidal thoughts or actions; new or worsening depression, anxiety, or panic attacks; agitation; restlessness; angry or violent behavior; acting dangerously; mania (frenzied, abnormally excited or irritated mood)...

http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000970

I'm not saying that there is a population that can't benefit from this pill. It could have a specific group of people. But we know what is gonna happen. It will be advertised on TV. Women are going to ask for this pill without doing any kind of research and there are going to be problems.

I have to be honest. I don't want teenage girls to have access to this medication. I don't think I'd want their moms to have it either.

Scary.

Gena Haskett is a BlogHer Contributing Editor. My Blogs: Out On The Stoop ( http://outonthestoop.blogspot.com ) and Create Video Notebook ( http://createvideonotebook.blogspot.com )

seghni 8 pts

I don't know if this is an answer,but I have struggled with a weight problem all my life,and in my case there are definite issues surrounding emotional eating and addictive behaviour...I became an exercise addict for a while during one period of dieting,and have previously had issues with tobacco addiction and even an unhealthy obsession with the internet (!)
I have lost major amounts of weight (over 100 lbs) three times in my life and each time regained it all..I'm heavy again now..I know how to lose weight but that's not the whole story by a long way..
I hope there will be something to help me in the future..unfortunate name though-anything with 'con' in the title puts me off!

Orchid64 5 pts

Anyone who thinks that any "easy" answer whether it be medication or diet pills will solve this problem is lacking in insight into the complexities of having a weight problem and an unhealthy relationship with food. One commenter said that gastric bypass is a "life-saving invention". It's not, and this will not be either. Gastric bypass is a gun to the head of people who want to lose weight, and it only stays loaded for awhile then people re-gain the capacity to over-eat. Many people who have had this surgery eventually regain a lot of weight (and more), die of complications, or have their life shortened because of the nutritional deficiencies this "life-saving treatment" brings upon them. Mutilating yourself is not an answer to obesity, nor is medicating your issues away.

The problem with weight is cultural and relates to lifestyles which have progressively supported unhealthy eating, a misunderstanding of portion sizes, and suppressed movement. The answer is in behavior modification and introspective therapy. People keep looking to medicine when the answer is in psychological restructuring. They look to medicine because it has a greater promise of a quick fix, but that fix is a lie. People need to be assisted in modifying their lifestyles and that means being taught how to take progressive, permanent steps as well as to know what drives their reliance on food as a medication.

It would also help if the cultures were less punitive toward obese people and were genuinely understanding of the fact that it is a symptom of either a physical or psychology disorder, or both. More quick fixes are not an answer, or at least not the right one.

These types of articles are not helpful because they provide false hope.

Melissa Ford 65 pts

I think -- like gastric bypass surgery -- that it sounds like a life-saving invention. Which is not to say that it will work for all people, but for the people who do benefit from it, it can literally be life saving.

There are no quick fixes -- even the things held up by the general public as quick fixes require dedication and work and a lot of time. There are no shortcuts. So I'm never worried about the invention acting as a shortcut -- only that people will become frustrated if they don't understand about the reality of the invention.

Melissa writes Stirrup Queens ( http://stirrup-queens.com ) and Lost and Found ( http://lostandfoundandconnectionsabound.blogspot.com/ ). Her novel about blogging is Life from Scratch ( http://www.life-from-scratch.com/ ).

Mrs. Yeater 5 pts

My family, especially on the paternal side, is very heavy, and for years I have struggled with my weight. Recently, I was right on the line of morbid obesity. It was scary. I did not like the way I looked (though I could deal with it through delusion) and especially the way that I felt. I wanted to lose weight and I wanted it NOW! Of course, that is not necessarily healthy and it was definitely not feasible.

It is difficult for me say definitively "Yea" or "Nay" to diet pills. When used in moderation along with diet changes, I feel that they can be very effective and have fewer negative side effects. The problem is that, in desperation, some may use more than is healthful as is the case with so many of the drugs released and retracted in the past.

I am an advocate for healthy eating patterns. It is about changing one's lifestyle and personality- how one looks at oneself and the world (which, physiologically, is like torture). It is HARD, but it works. In the end, though, if a person feels that it is the best way to go for their condition and discusses it with their physician, then use the medications. However, the only way they work, in the long run, is in conjunction with healthier living and eating.

I love my husband, I love my home, and I love to write ( http://mrsyeater.blogspot.com ).