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Gardasil -- The Three Faces of the HPV Vaccine...Fear, Facts, and Profits.

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Something very disturbing has been happening. Pharmaceutical companies are manipulating us with fear. It was bad enough when these companies began advertising prescription drugs on television. But now they have taken this tactic a step further; and began using fear for the life of our children, to persuade us that we need to get the HPV Vaccine for our daughters. This is the most sinister of abuse...using the love parents have for a child, to manipulate them through fear...for profit.

I will not be trying to convince anyone to get or not to get the Merck HPV Vaccine (Gardasil). What I will try to do with this post is address the facts surrounding the controversy, so all parents can make an informed decision about whether or not to get this vaccine for their child. I'll begin with my personal opinion...Never make a major decision for yourself or your child out of fear.

So now lets talk a bit about the facts, the ones you won't hear about on the ten second commercials that we are all seeing on television recently.

When detected in the early stages, the HPV virus is easily treated and rarely proceeds to cancer. Between 1955 and 1992 the number of cervical cancer deaths in the United States dropped by 74%. This decrease is largely attributed to the increased use of the PAP test. (The PAP is a diagnostic screening that can detect changes on a womens cervix even before cancer develops, as well as find cancer at the earliest stages when it is most curable.) Because of early diagnosis and treatment, the death rate from cervical cancer continues to decline about 4% each year.

Because the vaccine does not protect against all types of HPV, it will not prevent all cases of cervical cancer or genital warts. About 30% of cervical cancers will not be prevented by the vaccine, so it will be important for women to continue getting screened for cervical cancer (regular Pap tests). Also, the vaccine does not prevent about 10% of genital warts—nor will it prevent other sexually transmitted infections (STIs). So it will still be important for sexually active adults to reduce exposure to HPV and other STIs. -- from the CDC

LEBANON, N.H. - A lead researcher who spent 20 years developing the vaccine for human papilloma virus says the HPV vaccine is not for younger girls, and that it is "silly" for states to be mandating it for them. Not only that, she says it's not been tested for effectiveness in younger girls, and administering the vaccine to girls as young as 9 may not even protect them at all. And, in the worst-case scenario, instead of serving to reduce the numbers of cervical cancers within 25 years, such a vaccination crusade actually could cause the numbers to go up. -- read full article

Another important risk factor for developing cervical cancer is smoking. Smokers are at least twice as likely as non-smokers to develop cervix tumors. Smoking may also increase the importance of the other risk factors for cancer. Finally, being in a low socioeconomic group seems to increase your likelihood for developing and dying from cervical cancer. This may be because of increased smoking rates, or perhaps because there are more barriers to getting annual screening exams. -- read article

This year there will be about 3,670 deaths from cervical cancer in the United States, and the vast majority of these cases will be in patients who have never had a PAP test, or cervical screening. According to the U.S. Census Bureau, at the time I am writing this article there are approximately 301,718,307 people in the United States, and about half of those are women. Statistically speaking the death rate due to cervical cancer is very small. To put these numbers in even more perspective...

Every year, more than 500,000 American women die from cardiovascular disease. Heart disease actually kills more women than all forms of cancer combined. -- read full article

About 178,480 women in the United States will be found to have invasive breast cancer in 2007. About 40,460 women will die from the disease this year. Right now there are slightly over 2 million women living in the United States who have been treated for breast cancer. -- from American Cancer Society

From the CDC (National Vital Statistics) - 3,454 Americans died of malnutrition in 2001.

Here are a few more important facts about the HPV Vaccine:

How long does Gardasil last? Tests show that the vaccine

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CherubGirl 5 pts

My son developed Autism and it was made worse by vacine.  There is some stuff you can do, alot I believe of your problems experienced are from the Aluminuim in the vax.  If your suspeptable your bodys BBB Bloodbrainbarrier will be imparried, and as such you absorb stuff most people excreat...You need to get some ZEOLITES, this should help to remove stuff from your system.  Goodluck GOd be with you

ginamarie 5 pts

I received my first Gardisil vaccine on August 7, 2007. Two days later I started to break out in hives. I broke out in hives every night for 7 months. It has been two years since my first vaccine and I still break out about 2-3 days every week. Every doctor I went to told me it was stress. I never related the vaccine to my sickness. In the beginning it was just allergies. After three months it was possibly some type of autoimmune disease. When everything came back normal (except my WBC count being low and still is) I was just “crazy”. I decided to get my next two vaccines. I had severe side effects about an hour after the third one in August 2008. I could feel every bone in my body from my hips up; they hurt. My skin hurt, it hurt to wear clothes and to take a shower. I had a headache so severely that I felt like it burnt my brain. I called my doctor’s office and they told me it was normal. Since, I have had arthritis in my hands. Fatigue has also been a side effect. Some days I’m so tired that I don’t want to get out of bed. I have spent two years trying to find out what was wrong with my body. It wasn’t until last week that I finally put two and two together. The dates of my health problems and when I received my vaccines are undenyable. I contacted my OB/GYN who said that there are NO adverse side effects to this vaccine. This vaccine has destroyed my health and almost destroyed my mind. I graduated in may 2009 with a B.S. in Chemistry and high hopes to go to medical school. Every physician I have gone to in the past two years has made me feel like I’m completely insane and just too stressed out. I decided that if I couldn’t deal with the stresses of everyday living, then how could I become a physician? I’m taking a year off from school and have zero stress. I still wake up in the mornings with stiff hands. I still break out in hives 2-3 times every week. The only thing I’m guilty of is listening to physicians telling me I’m stressed out while knowing in my gut that it was something else. Sheer stupidity led me to get the next two vaccines… I had enough health problems and I sure didn’t need anymore, is what I thought. PLEASE PROTECT YOUR FRIENDS AND DAUGHTERS. DO NOT LET THEM GET THE GARDISIL VACCINE. I WOULD RATHER HAVE CERVICAL CANCER!!!!!

With all of this being said, I cannot extract the vaccine from my body. My physician's office is not helpine me at all. They are telling me that their Merck rep says there are no known adverse side effects. Apparently Merck offers the only "accepted" medical studies. They are telling me that there is a lot of information that can be read on the internet, but that it's false and not medically accepted. I need to know what diseases can be onset be the HPV vaccine. I do not have lupas and is the only one I can find. I am at this point hopeless, helpless, and since graduating college uninsured as well. Can someone point me in the right direction? Are these side effects ever going to go away or am I screwed for life?

LivingLong 5 pts

What happened is those with greater intelligence (and getting big 'incentives') want to protects us from our own stupidity.  An interesting twist on this is the argument put forth by the vaccine advocates: Those of us who aren't falling all over ourselves to go get all the latest and greatest vaccines are putting civilization at risk by running around dirty and infested by all kinds of communicable diseases.  I guess they never heard of the natural ways to keep healthy and well.

Don't get discouraged - Many are questioning the message that BigPharma + BigMoney = Great health.

missliss 5 pts

I was against Gardasil, before reading this.  Your article was very well written, and covered the issues.  I agree that someone should make their own decision, that is best for their child.  Lots of politicians are backed by lobbyists, that work for these drug companies.  They get paid tons of money, to get lawmakers to pass legislation, that favors the drug companies.  It is really sick, and sad, that they can impose such stupidity on the people of this country.  Fine make the vaccine available, let parents be informed and make a decision, but dont make it mandatory.  That is ludicrous.  Especially for a child as young as nine.  Give me a break, how many 9 yr olds are sexually active.  This is a STD, we are talking about.  I for one, will not allow this vaccine given to my child, especially at 9.  One more thing, why is it always young girls that are targeted when these things come out.  Are there not young boys that are sexually active.  Why are they never made a vaccine, to help not get an STD?  Not that I would give that to my son either, but it never occurs, to even argue about it.

dinexdashed 5 pts

Hi,

I've been trying to find information EVERYWHERE as to how long the 1st shot lasts in your system. I noticed you posted that the entire three shots lasts about 4 years, but I only received the 1st shot.

The reason I'm asking is because I've decided not to continue with the shots as they have made me very sick. My symptoms have included: severe nausea & dizziness, fever, feeling weak/faint, very little appetite, etc. I got my first shot on July 15th and a few days later started feeling the effects. It feels like I'm FINALLY starting to get a little better, but I still get waves of nausea & dizziness. My doctor doesn't believe me when I say I think its the Gardasil (surprise, surprise). 

All I want to know is an approximate time frame for this junk to be out of my system so I can start feeling better!

 Thanks.

cmc1154 5 pts

Pelvic pain
Severe stomach pain
Pain, swelling or stiffness in joints
Pain, swelling, redness or itching at the injection site
Mild fever
Nausea, vomiting, diarrhea, upset stomach (always)
Dizziness (often)
Runny or stuffy nose, sore throat, cough
Muscle pain and general weakness (constant)
Fainting (2 times)

My daughter has recvd 2 of the vaccines/shots and will not get the third. She has been hospitilized (ER) twice over the past 5 months. Once, by ambulance from her college dorm. Diagnosis: NONE-stress etc due to college life. They ran blood tests, ultrasound for ? of gallbladder disease/stones--all negative. Next, they want to run GI series. Of course, I will have these test, in fear that there could be something else but I am so sceptic now after reading all these reports and blogs...

My daughter is an athlete, plays college Lacrosse, and is in such pain all the time now. She NEVER had any of these symptoms prior to recving this vaccine. PLEASE, think twice about having your daughter receive this vaccine. Educate yourself and her about the ramifications of this drug. Teach her to abstaine instead of feeling the pain from this drug... even death (God forbid).

urbanpedestrian 5 pts

Thanks for this discussion, Catherine. I never ceases to amaze me what absolute blind faith people have in pharmaceuticals -- as if they were in business to make us better. Conglomarates that own drug companies are very diverse and usually own a whole host of other even less savory companies; companies responsible for generating toxins in our air and water -- toxins which create the very diseases the pharmaceuticals claim to "cure". The whole concept of "curing" cancer is a fallacy. Cancer will never be cured. Zillions of dollars have been collected for cancer cures and more and more people are getting it and dying from it. The key must be cancer prevention -- not through more drugs (i.e.: questionable vaccines), but through less exposure to toxic substances in our every day lives. I've talked about this issue and the HPV vaccine specifically on my blog (www.urbanpedestrian.blogspot.com ( http://www.urbanpedestrian.blogspot.com )), so I won't go on and on now.

Catherine Morgan 5 pts

This is information that has been brought to my attention, and that I think is very important to share with anyone concerned about this vaccine.

(Washington, DC) -- Judicial Watch, the public interest group that investigates and prosecutes government corruption, today released documents obtained from the U.S. Food and Drug Administration (FDA) under the provisions of the Freedom of Information Act, detailing 1,637 reports of adverse reactions to the vaccination for human papillomavirus (HPV), Gardasil. Three deaths were related to the vaccine. One physician’s assistant reported that a female patient “died of a blood clot three hours after getting the Gardasil vaccine.” Two other reports, on girls 12 and 19, reported deaths relating to heart problems and/or blood clotting. -- read full article ( http://www.judicialwatch.org/6299.shtml )

Information on the side affects of this vaccine are continuing to come out, and adding to the controversy of whether the benefits outweigh the risks of this vaccine.

As of May 11, 2007, the 1,637 adverse vaccination reactions reported to the FDA via the Vaccine Adverse Event Reporting System (VAERS) included 371 serious reactions. Of the 42 women who received the vaccine while pregnant, 18 experienced side effects ranging from spontaneous abortion to fetal abnormities.

Side effects published by Merck & Co. warn the public about potential pain, fever, nausea, dizziness and itching after receiving the vaccine. Indeed, 77% of the adverse reactions reported are typical side effects to vaccinations. But other more serious side effects reported include paralysis, Bells Palsy, Guillain-Barre Syndrome, and seizures. -- ( http://www.judicialwatch.org/6299.shtml ) -- read full article ( http://www.judicialwatch.org/6299.shtml )

These new findings bring into greater question the government attempting to mandate this vaccine for young girls.

“The FDA adverse event reports on the HPV vaccine read like a catalog of horrors,” stated Judicial Watch President Tom Fitton. “Any state or local government now beset by Merck’s lobbying campaigns to mandate this HPV vaccine for young girls ought to take a look at these adverse health reports. It looks as if an unproven vaccine with dangerous side effects is being pushed as a miracle drug.”

Judicial Watch filed its request on May 9, 2007, and received the adverse event reports from the FDA on May 15, 2007. -- adverse event reports ( http://www.judicialwatch.org/6299.shtml )

In following-up on this information I came across article after article that were still referring to Gardasil as a "cancer" vaccine. Gardasil is a vaccine that "may" prevent the HPV virus...Gardasil is NOT a cancer vaccine. I find this very troubling because there is a very big difference between a vaccine that prevents cancer and a vaccine that prevents a virus that "may" cause cancer. This is a "purposeful" deception by Merck to scare parents into getting this vaccine for their daughters.

A recent study, published in the New England Journal of Medicine, also questioned the general effectiveness of Gardasil.

If this practice is not illegal...it is most certainly unethical. But, it is working...and the reason it is working is because the "media" is perpetuating this idea by continuing to repeat it. It is very important to remember that just because you "hear" something 100 times, that doesn't make it true. It seems to me that it is the difference between "facts" and "brainwashing". (ie: Iraq had weapons of mass destruction. "No, they actually did not" - Bin Laden was responsible for 9/11. "No, we know who was responsible for 9/11, and it was not Bin Laden") This is a practice that has been extremely affective for politicians, and why we see so many "attack" ads on television around election time. Now the pharmaceutical companies are taking a page from the political campaigners, and manipulating facts to deceive the American people. The question is...are we going to let them get away with it? I hope not.

I challenge the media to stop allowing politicians and corporations to deceive the American people, I challenge them to report the facts (not talking points, and false accusations).

Contributing Editor Catherine Morgan
also at Women 4 Hope ( http://women4hope.wordpress.com/ ) and CatherineBlogs.com ( http://www.catherineblogs.com/ )

martre66 5 pts

Catherine Morgan Thank you Catherine for sharing all of this useful information.I am a single father of a 13 year old girl.I have not allowed them to inject this poison into my daughter.They have asked twice.The first time I heard of HPV vaccines my mind instantly jumped to "population control".And after further research I have found that there are similarities between Gardasil and long term birth control.

Catherine Morgan 5 pts

Thanks for your comment and your link. It is so important for people to understand that Gardasil is NOT a cancer vaccine. I agree with you 100%...and I hope anyone interested in learning more about the HPV virus and this vaccine will check out your very informative site. Thank you again for your comment.

***Since my last update on this issue I have been made aware of additional information, and I am working on another update for this post. I hope to have an update ready to post by tomorrow.

Contributing Editor Catherine Morgan
also at Women 4 Hope ( http://women4hope.wordpress.com/ ) and CatherineBlogs.com ( http://www.catherineblogs.com/ )

ateets3030 5 pts

Marketing this vaccine as a "cancer" vaccine is not only wrong, it's illegal. If this product was anyother thing, the FDC would be cutting the ads in no time, no questions asked. This vaccine prevents against four types of a VIRUS not cancer.

It's also interesting to note that considering the fact that most cervical cancer takes 10 years to develop from pre-cancerous cells AND the fact that Merck has only been studying the vaccine for 5 years; it makes you wonder how they are able to claim that it prevents cancer.

Also, most of the women who get diagnosed with invasive cervical cancer hadnt had a pap test within the previous five years (and most of those women NEVER even had a pap test in their lives!).

Oh well, for more information regarding HPV and the vaccine, you can visit www.YourRight2Choose.org ( http://www.YourRight2Choose.org ) , a non profit organization in Florida focused on education the public about HPV.

Catherine Morgan 5 pts

Hi Belinda -- This vaccine is touted as a vaccine against cancer, but it is simply a vaccine against some of the viruses that may cause this type of cancer.

You are correct, a vaccine against cancer would be wonderful. Unfortunately, this Gardasil vaccine if nothing more than a vaccine against a few (treatable) viruses.

Not that it shouldn't have it's place in the market, it just shouldn't be touted as something it is not.

Thank you for your comment.

Catherine Morgan
Women 4 Hope ( http://women4hope.wordpress.com/ ) and Be The Change You Want To See In Yourself ( http://catherinemarie.wordpress.com/ )

Catherine Morgan 5 pts

Thank you for the Gardasil Update. I think it is very important to keep this post updated with all of the facts, so families can make a fully educated decision on whether they should vaccinate their daughters.

Catherine Morgan
Women 4 Hope ( http://women4hope.wordpress.com/ ) and Be The Change You Want To See In Yourself ( http://catherinemarie.wordpress.com/ )

Creatively Belle 5 pts

I think there are a few themes coming out here and it is interesting how information is passed about.

Yes, pharma companies are into profits, yes, advertising is often designed to be emotionally powerful, yes, we do need to be active in our democracies and question our governments and yes, we do need to be researching medical developments so we're well informed and capable of intelligent choices.

I've never thought pharma companies to produce balanced and unbiased information about their products. It is certainly the role of agencies giving permission for the sale of drugs to thoroughly test and research the products to know what they are judging.

If these agencies are influenced by lobby groups or influenital individuals or businesses then there is a serious problem and must be fixed.

As with all drugs time will tell who did their job properly and who didn't.

But a start has to be made and to me finding ways to vaccinate against cancer is a great thing that can lead to even more amazing results. Locally for us the government is covering the cost of the vaccinations for girls as it is seen as a cheaper option than the health costs in years to come.

Here's to a vaccination or cure for all cancers that breaks hearts and steal joy.

Best wishes,
Belinda

Creatively Belle - Great Earring Holders and Jewelry ( http://www.creativelybelle.com/ )

mhatrw 5 pts

GARDASIL is a new vaccine from Merck that has now been clinically shown to strongly protect against two dangerous, cancer associated HPV strains -- HPV 16 and HPV 18 -- for at least three years among women previously unexposed to these strains. HPV 16 and HPV 18 are currently associated with 70% of all cervical cancer cases. Medical experts hope that this means that GARDASIL could potentially end up reducing cervical cancer contraction rates by as much as 70%. So far, the limited clinical evidence available tells a very different story.

Because so few women contract cervical cancer and because cervical cancer's average latency period after initial HPV infection is over 20 years, it would take hundreds of thousands of subjects and/or decades to conclusively demonstrate that GARDASIL actually reduces cervical cancer rates in any population. Therefore, the end points used to demonstrate GARDASIL's effectiveness against cervical cancer in GARDASIL's two biggest studies (FUTURE I & II) were chosen to be the number of high grade cervical lesions -- or alternatively, the number of patients with high grade cervical lesions -- prevented over a 3 year period. High grade cervical lesions consist of grade 2 and grade 3 cervical intraepithelial neoplasias and all adenocarcinomas in situ. Among women in the USA, the vast majority of high grade cervical lesions either regress spontaneously or are successfully treated. However, the FDA currently considers high grade lesions to be acceptable surrogate outcomes for cervical cancer.

Here are the most recent and by far most comprehensive clinical results for GARDASIL in terms of reduction of high grade cervical lesions over a three year period.

For the general 16 to 26 year old population

FUTURE I

For the unvaccinated group, there were 194 total high grade lesions diagnosed -- 101 associated with HPV 16 & 18 and 93 associated with other dangerous, cancer causing HPV strains. For the vaccinated group, there were 182 total high grade lesions diagnosed -- 76 associated with HPV 16 & 18 and 106 associated with other dangerous HPV strains. That's a 6% overall decrease high grade HPV lesions but a 14% increase in other dangerous unprotected HPV strains for the vaccinated group.

FUTURE II

For the unvaccinated group, there were 361 total high grade lesions diagnosed -- 207 associated with HPV 16 & 18 and 154 associated with other dangerous, cancer causing HPV strains. For the vaccinated group, there were 281 total high grade lesions diagnosed -- 103 associated with HPV 16 & 18 and 178 associated with other dangerous HPV strains. That's a 22% overall decrease high grade lesions but a 16% increase in high grade lesions associated with dangerous unprotected HPV strains for the vaccinated group.

In terms of individual subjects rather than lesions (some subjects had multiple high grade lesions), vaccinated patients were 17% less likely to develop high grade cervical lesions overall but 15% more likely to develop high grade cervical lesions associated with dangerous unprotected HPV strains.

Combined FUTURE I & II

For the unvaccinated groups, there were 555 total high grade lesions diagnosed -- 308 associated with HPV 16 & 18 and 247 associated with other dangerous, cancer causing HPV strains. For the vaccinated groups, there were 463 total high grade lesions diagnosed -- 179 associated with HPV 16 & 18 and 284 associated with other dangerous HPV strains. That's a 16.6% decrease in overall high grade lesions but a 15.0% increase in high grade lesions associated with dangerous unprotected HPV strains for the vaccinated group.

For the sub-population of subjects who tested negative for both HPV 16 and 18

FUTURE I: Merck did not publish these results.

FUTURE II: Vaccinated patients were 27% less likely to develop high grade cervical lesions overall and at most 8% more likely to develop high grade cervical lesions associated with dangerous HPV strains other than HPV 16 & 18.

For the sub-population of subjects who tested positive for either HPV 16 and 18 or both

FUTURE I: Merck did not publish these results.

FUTURE II: Vaccinated patients were 9% less likely to develop high grade cervical lesions overall and at least 105% more likely to develop high grade cervical lesions associated with dangerous HPV strains other than HPV 16 & 18.

This is not an opinion. These are Merck's very own published clinical results for FUTURE II ( http://content.nejm.org/cgi/content/full/356/19/19... ).

Catherine Morgan 5 pts

Here are some recent articles you may want to weigh in on...

Is Gardasil Worth the Shot? ( http://www.latimes.com/features/health/la-he-vacci...,1,2196232.story?coll=la-headlines-health )

This is what MERCK is saying ( http://www.merck.com/newsroom/press_releases/produ... ) about the newly released report.

Interestingly enough this link for Medical News Today ( http://www.medicalnewstoday.com/medicalnews.php?ne... ) seems to be an exact copy of the above news release from Merck.

This seems to me to further blur the line between news and advertising. The media appears to just pick-up on Corporate talking points, and present them as news. This does not benefit the public, and the news media should discontinue this practice at once. (Not only on this topic, but on every topic they are currently doing this...Including but not limited to politics, global warming, and gas prices).

Merck: Making a Big Pharma Comeback ( http://biotech.seekingalpha.com/article/35562 )

From The New York Times - Health ( http://www.nytimes.com/2007/05/12/health/12cancer.... )
CONCORD, N.H. — "A vaccine for a sexually transmitted virus that causes cervical cancer may be creating controversy across the country, but in New Hampshire physicians say so many people want it that they cannot satisfy the demand."

Me, in response to the above: It seems irresponsible to me for a State or physician to give a controversial vaccine simply because the public is "demanding" it. 1) The public can and may be swayed by misleading information being provided by Merck. 2) The public did not go to medical school (although they should be informed and educated on these issues), the deciding factor on a whether a vaccine's benefits outweigh the risks, should be made by a medical professional. When and if there are reported consequences to this vaccine, the physicians who administered this drug should not be allowed to "blame" the outcome on the public demands. 3) What if the public started demanding Morphine for headaches? Medication decisions need to (and always have been) made by the physician. The medical community bares this responsibility, not the public.

Catherine Morgan
Women 4 Hope ( http://women4hope.wordpress.com/ ) and Be The Change You Want To See In Yourself ( http://catherinemarie.wordpress.com/ )

Catherine Morgan 5 pts

Interestingly enough...as I am following up on the above update...I came across this:

From Vaccine Rx ( http://www.vaccinerx.com/news/cervical-cancer/gard... )

Elaborate information on the study came up in the May 10, 2007 issue of The New England Journal of Medicine.

A consensus was then reached by the researchers that Gardasil was essentially effective against the targeted strains of HPV and produced a relevant decrease in anogenital disease.

This is just one of many articles I have seen "evaluating" this May 10th report by the New England Journal of Medicine. It smells like "spin" to me. It seems to me that this study is being misrepresented by many in the media.

I'm going to continue to look into this, and update accordingly. If anyone else can weigh-in on this controversy or has links that I should check out...I would welcome your input. Thank you.

Catherine Morgan
Women 4 Hope ( http://women4hope.wordpress.com/ ) and Be The Change You Want To See In Yourself ( http://catherinemarie.wordpress.com/ )

Catherine Morgan 5 pts

As promised, I am continuing to update this post with all important information coming out on this subject.

So, when the following information was sent to me by another BlogHer member...I wanted to post it immediately. Thank you Kelly Anne for summarizing this article from a medical journal, so we will all be able to understand it.

SECOND UPDATE:

To summarize this article published in the New England Medical Journal May 10th: HPV Vaccination - More Answers, More Questions ( http://content.nejm.org/cgi/content/full/356/19/19... )

1. In the FUTURE I trial, GARDASIL demonstrated no clinical efficacy among the general subject population for overall reduction in the rates of grade 2 and grade 3 cervical intraepithelial neoplasia and adenocarcinoma --the only recognized precursors to cervical cancer.

2. In the larger FUTURE II trial, GARDASIL demonstrated no clinical efficacy among the general subject population for overall reduction in the rates of grade 3 cervical intraepithelial neoplasia and adenocarcinoma -- the strongest (and many would argue only valid) precursors to cervical cancer.

3. Extrapolating from GARDASIL's very limited clinical "success" (in the FUTURE II study only) against grade 2 cervical dysplasias (40% of which regress spontaneously), 129 women would be have to be vaccinated (at a cost of about $60,000) to prevent a single grade 2 cervical dysplasia.

4. GARDASIL's protection against cancer associated HPV strains 16 and 18 appears to cause a disproportionate increase in of pre-cancerous dysplasias associated with other HPV strains associated with cervical cancer "raising the possibility that other oncogenic HPV types eventually
filled the biologic niche left behind after the elimination of HPV types 16 and 18."

5. Even if you segregate out the women who hadn't been previously exposed to either HPV 16 or 18, we are talking about just a 17% decrease in all high grade dysplasias (266 out of 6080 vs. 219 out of 6087) -- many of which would spontaneously regress without treatment. So we would have
vaccinate 129 women (at about $500 for the three shot regimen) to avoid a single, eminently treatable dysplasia. That's about $60,000 per dysplasia prevented.

Kelly Anne says:

I myself would add that we currently have only 3 years of follow up to go on in terms of both GARDASIL's safety and efficacy among the 16 to 26 year female population, no data concerning its efficacy among 9 to 12 year old girls and only 18 months of follow up on less than 600 total preteen girls in terms of safety data about GARDASIL within its targeted population.

See also:

JAMA - Mandatory HPV Vaccination ( http://jama.ama-assn.org/cgi/content/full/297/17/1... )

And:

Viral Marketing - Questions on Efficacy Cloud a Cancer Vaccine ( http://online.wsj.com/article_email/SB117668541991... )

It appears that the vaccinated cohort sees a 20%+ increase in high grade cervical dysplasias caused by cancer-associated HPV strains other than HPV 16 and 18.

One possible explanation is that HPV 6 or HPV 11 infections are antagonistic to more dangerous HPV infections:

from - vir.sgmjournals.org ( http://vir.sgmjournals.org/cgi/content/full/80/11/... )

Thank you Kelly Anne for sending me this important information.

Catherine Morgan
Women 4 Hope ( http://women4hope.wordpress.com/ ) and Be The Change You Want To See In Yourself ( http://catherinemarie.wordpress.com/ )

Lisa Stone 17 pts

This is really helpful. And scary. And helpful. And...

Lisa Stone
BlogHer Co-founder ( http://www.blogher.com/member/lisa-stone )
Surfette ( http://surfette.typepad.com )

Catherine Morgan 5 pts

In an effort to keep BlogHer readers informed of additional information coming out regarding Gardacil...I will be adding to this post periodically with updates.

FIRST UPDATE:

Nearly a year after a controversial cervical cancer vaccine won federal approval and hit the market to a whirlwind of interest from doctors and parents, at least two UCSF physicians are warning against widespread use of the drug until much more extensive studies are complete. -- full article ( http://www.sfgate.com/cgi-bin/article.cgi?file=/c/... )

In an editorial published in today's New England Journal of Medicine

"At this stage, vaccination can still be considered experimental," said Dr. Karen McCune, an associate professor of obstetrics and gynecology at UCSF, who co-authored the editorial. "To be discussing mandatory vaccination when the main clinical trials are still ongoing seems extremely premature. We're feeling like the enthusiasm is driving policy rather than data." -- full article ( http://www.sfgate.com/cgi-bin/article.cgi?file=/c/... )

Cervical cancer is the second-most common cancer among women worldwide and the third-most fatal, causing 290,000 deaths a year. The disease is rare in the United States, where regular screening for adult women catches most precancerous cases; about 3,700 American women die of cervical cancer every year.

But the primary concerns of doctors like McCune are that long-term side effects of the vaccine are unknown -- the most recent study followed women for three years -- and that earlier research hasn't considered what effect the vaccine has on the remaining 13 strains of HPV that also cause cervical cancer.

It's possible, McCune said, that the remaining strains may fill a "niche" left if the two most common strains are wiped out entirely. If that happens, the vaccine might not make any difference on overall cervical cancer rates, she said. -- full article ( http://www.sfgate.com/cgi-bin/article.cgi?file=/c/... )

IN A RELATED STORY..

Manufacturing problems have halted production of a four-disease combo vaccine made by Merck & Co.

Last year, the government recommended the second chickenpox shot because of outbreaks among schoolchildren, apparently due to waning potency of the vaccine. -- you can read the whole article here. ( http://news.yahoo.com/s/ap/20070510/ap_on_he_me/me... )

Catherine Morgan
Women 4 Hope ( http://women4hope.wordpress.com/ ) and Be The Change You Want To See In Yourself ( http://catherinemarie.wordpress.com/ )

Catherine Morgan 5 pts

Thanks for getting on your soapbox for a bit, and for your support.

Catherine Morgan
Women 4 Hope ( http://women4hope.wordpress.com/ ) and Be The Change You Want To See In Yourself ( http://catherinemarie.wordpress.com/ )

Maria Niles 7 pts

Money appears to be the motivator for Merck

I'd say money absolutely is the motivator. Merck is a business, businesses exist to make profits and publicly held corporations have an obligation to maximize those profits for the shareholders. Merck, I'm sure, would also argue that they need to maximize the profit on their sales so that they can fund the research and development of more life-saving drugs.

That's not to say that I think drug companies are evil and don't give a damn about offering products that offer real health benefits. And I'm sure that this vaccine will save lives. If I had a daughter I'd have her take it because I've seen enough of my friends deal with HPV infections the got no matter how "good" or "careful" they were. But I'm also not surprised that they would advertise the drug and shout the possible benefits and whisper the potential risks.

Also, preventative care (e.g. screenings that catch changes before disease develops rather than using a drug to stop those changes from occurring) vs. drug treatment doesn't benefit the bottom line so there's little incentive for a drug company to promote that behavior. Follow the money. Who profits from screening and non-drug treatments? Conceivably doctors and hospitals but their lobbies aren't as powerful as drug and insurance companies and still someone has got to pay for those screenings which is not so profitable for insurance companies. Which path offers more benefits and savings to us collectively as a society? And why aren't we lobbying for the change that benefits us most even if it may not be the most profitable for the drug companies?

Insurance companies also are motivated by seeking profit. They realize more profit the fewer claims they have to pay. So if they only insure young, healthy people and then refuse to cover anyone who has shown a need to take any drug no matter how seemingly minor (e.g. allergy meds) then drug companies are going to have to find another way to find someone to pay for their product. Voila - lobby the government to mandate it to go along with the lobbying done to prevent the government from negotiating for price discounts.

I am not surprised that Merck or any other drug company is seeking to profit from the sales of their products. I am surprised that so many Americans want to retain the system of healthcare that we currently have in this country rather than demand change because they erroneously think it will result in a system that is "government medicine" with politicians and bureaucrats giving exams.

I am hopeful that the more people like you, Catherine, bring these issues to our attention the greater the chance that the demand for change will grow. Thanks!

I'll hop off my soapbox now. This issue works me up into a bit of a tizzy. ;^)

Denise 94 pts moderator

Money is the motivation behind all pharma - it's what drives the company and makes new drugs (and old drugs) possible. I don't really see the point of getting all bent out of shape over Merck and Gardasil and while applauding AstraZeneca.

I'm confused by the people who are annoyed with Merck (and yelling MONEY!!!) and yet support breast cancer month, pink ribbons and the pharma who is making more money scaring women about breast cancer and selling their breast cancer drugs than Merck will probably ever make off of Garasil. Breast cancer month was started by pharma (AstraZeneca) to increase their sales and oh boy has it worked.

That's what is so troubling to me.

I'm a lot less angry with Merck who is trying to PREVENT HPV and possible cervical cancer with a drug than I am with AstraZeneca who has absolutely no interesting in preventing breast cancer through drug treatment.

Make an informed decision - and think about whether you prefer a drug that may help prevent one type of cancer or a drug that may or may not cure you once you find yourself with another form of cancer....

~Denise
Fast Times @ Homeschool High ( http://fasttimes.clubmom.com ) & Flamingo House Happenings ( http://www.flamingohouse.net</a )

Catherine Morgan 5 pts

Hi Margalite...

We all should be asking "What is motivating Merck?"

Money appears to be the motivator for Merck, and that is what is so troubling to me.

Catherine Morgan
Women 4 Hope ( http://women4hope.wordpress.com/ ) and Be The Change You Want To See In Yourself ( http://catherinemarie.wordpress.com/ )

Catherine Morgan 5 pts

Thanks Nordette...I really do believe that knowledge is power, and that's why I tried to include as much information as I could in this post.

I also wonder whether the vaccine lulls people into a false sense of security about risks for HPV.

This is a really huge concern of mine. The only reason that we have seen such a large drop in death rates from cervical cancer, is because of early detection. I'm afraid that if women think they have reduced their risk of HPV by 70%, they will be more inclined to not follow-up with routine PAP tests...this could have devastating repercussions.

I hope Merck will spend as much money on an education campaign informing women of all the reasons they need to continue with routine PAP testing, as they have on their promotion of Gardasil.

Catherine Morgan
Women 4 Hope ( http://women4hope.wordpress.com/ ) and Be The Change You Want To See In Yourself ( http://catherinemarie.wordpress.com/ )

margalite 5 pts

Hi Catherine,

I am pleased to make my first comment at BlogHer on one of your posts.

As you already read my blog, you know I am a straight-talker. First some history, then some science, then some personal commentary.

We all should be asking "What is motivating Merck?".

I believe that this HPV vaccine is totally money-motivated and if you want to know the real Power machination-in-the-shadows, then learn all you can about the history of Merck and Bayer, especially, but some of the others in the pharmaceutical cartel, like Eli Lilly etc, came under the Globalist Power-mongers, too, albeit later in history.

These companies appear to be potent money makers for The New World Order // Illuminati // Secret Global government --- name it what you will. The NWO has a policy to implement population-control, in many ways: famine, war, pestilence and more. They are desperate at 6 billion people to use every means. Population "control" has been implemented many times during the approximately 8,000 years they have been in continuous power.

Also learn about the US Army's Biological Lab at Fort Dettrick, Maryland. It's history will really shock you in the context of the US government-within-a-government which only President Dwight Eisenhower, in a speech when leaving office, and Jimmy Carter, very early in his Presidency, actually had the courage to expose.

When I was living in the metro Washington DC area, I actually heard Carter, on local TV, say this live, before the TV went mysteriously blank right afterwards! He never mentioned it again, as you can bet he was threatened not to. I remembered it so clearly because the statements were SO strange, for me at that time, as I had NO knowledge of any Globalists' machinations and agendas.

Yes the global (and especially American, British, German) military-industrial complex is an organized, potent, lethal structure and it runs everything behind the scenes, and drug companies are at the top of the list. No global elected leader is any more than a pawn, and no royal is either. Both Eisenhower and Carter were quite clear about that, as was the Meiji Emperor in Japan, a few centuries ago.

The public face of the NWO is only the uppermost echelons of the Council of Foreign Relations, the Bilderberger Group, The Council of Rome, the Jesuit Secretary-General's office, the World Trade Organization, the 33rd degree Masons and the World Bank.

And there is also a personal side of this debate for me --- I have a Mom who had cervical cancer, I know exactly what the scary diagnosis can mean to a family (she's still alive, 45 years later). And, I have an 8 year old grand-daughter, in Texas, for whom I am worried about her being told she MUST be inoculated.

I do not believe all this hype at all. I do believe that cancer is an opportunistic and naturally-occurring consequence of our body's overacidity --- which is caused by stress, life-style choices and ineffective natural metabolic processes. It can be eradicated (read that carefully, I did not say irradiated).

Learn more about this already proven New Biology paradigm from renowned microbiologist Dr. Robert O. Young, PhD, DSc, ND at www.phmiracleliving.com ( http://www.phmiracleliving.com )

Viruses, like pappiloma, as well as bacteria are able to proliferate in acidic body-cellular environments. They are not the disease and don't "cause" it --- they are more like just bystanders in most cases --- to a self-initiated, triggered cellular process of personal destruction (dis-ease). Make your body naturally alkaline, as is your birthright, and you can be largely or completely free of dis-ease.

Prescription drugs and vaccines just add to your acidic load. So really think long and hard before giving your children something which is not needed, especially if they are leading a balanced or almost-balanced, harmonious Life --- which is what we all hope to help them learn and live (and we need to be doing the same).

I hope no child gets this vaccine, and especially that no child is forced to get this vaccine. Do not act out of Fear. Do act with Knowledge and Courage.

Best to all ---
Margalite

P.S. Please visit me at: http://diabetesdietdialogue.wordpress.com
"Everyone knows someone who needs this information!" (TM)

Nordette Adams 10 pts

Catherine, I'm biased and automatically become distrustful when it comes to the government mandating anything from which a corporation profits. I understand that cervical cancer is a terrifying disease, but I also wonder whether the vaccine lulls people into a false sense of security about risks for HPV. Not much to be done about perception.

I also have in my living memory cases of government approvals of drugs and studies that later proved as harmful as the evil they were promoted to stop. As a result, I've been mum on the Gardasil debate. The first commercials rubbed me the wrong way and I was not surprised to hear about Merck's lobbying efforts. It just doesn't sit well with me. Right call to end your post with knowledge is power.

"Love is liquid. Brew and be drunkards!" ~~Nordette ( http://jerseygoddess.blogspot.com/2007/04/april-is... ) And here's a link to the blog ( http://jerseygoddess.blogspot.com/ ).

Catherine Morgan 5 pts

It seems to me that when a small amount of controversy began to surround this vaccine...Merck took a small step back...but didn't address the controversy...(that troubles me). It's like they know our attention span is short when it comes to news like this. Now they are jumping back on the band-wagon...just picking-up where they left off...(without addressing any concerns)...just playing on heart strings.

I think the reason I can't let this issue go, is because there is no attempt by Merck to address any of the controversy. That makes me think they either don't have an explanation, or they just think they are above needing to give an explanation, (either way it is troubling to me).

Catherine Morgan
Women 4 Hope ( http://women4hope.wordpress.com/ ) and Be The Change You Want To See In Yourself ( http://catherinemarie.wordpress.com/ )

ByJane 5 pts

Since I wrote that post, the media blitz has gone through several waves. Merck pulled their ads because of the criticism against them. Now they're running them again. Makes me wonder what happened.

btw, I can't get to my post through the url I gave above. This one should work. http://byjane.blogspot.com/2007/03/where-do-you-st... ( http://byjane.blogspot.com/2007/03/where-do-you-st... )

By Jane
ByJane.blogspot.com

Catherine Morgan 5 pts

Hi Jane...

Since I wrote that, Merck has pulled back on the advertising, but the controversy over the vaccine goes on. I certainly don't want to be put in the same pot as those who are against it for religious or moral reasons. But I still can't help feeling that the hoo-hah around the vaccine is--I don't know--a bit too loud. Is it that this is the first vaccine for cancer that's been found so let's shout it from the rooftops? Or that we're having some very sad, slow newsdays these past months?

I also found the media blitz troubling, it seemed odd that several Merck "talking points" were going round and round without any question to their validity.

Catherine Morgan
Women 4 Hope ( http://women4hope.wordpress.com/ ) and Be The Change You Want To See In Yourself ( http://catherinemarie.wordpress.com/ )

ByJane 5 pts

My post on this topic ran on March 21st and referenced a response I made to NPR when they ran a promo for the vaccine. You can read what I said here. ( http://http://byjane.blogspot.com/2007/03/where-do... )

By Jane
ByJane.blogspot.com

Catherine Morgan 5 pts

Knowing the facts and making an informed decision, that is the most important thing. I'm lucky that I don't have to make the decision right now for my daughter, I'm really not sure what I will actually do when the time comes. But, I think the decision to use this vaccine should be left to the parents and not the government.

Catherine Morgan
Women 4 Hope ( http://women4hope.wordpress.com/ ) and Be The Change You Want To See In Yourself ( http://catherinemarie.wordpress.com/ )

Catherine Morgan 5 pts

I agree...the "mandatory" part is the thing that gets me the most mad. I'm not sure yet if I will get this vaccine for my daughter. But, I do know that I want it to be my choice.

Catherine Morgan
Women 4 Hope ( http://women4hope.wordpress.com/ ) and Be The Change You Want To See In Yourself ( http://catherinemarie.wordpress.com/ )

Denise 94 pts moderator

Many parents refuse to have their children vaccinated and their kids are still permitted to attend public schools.

I'm pro-vaccine for a lot of reasons but I'm also pro-choice. If you don't want to vaccinate your kids, then don't. Get the waiver from the school district that is available in every state I've lived in and many more that I've researched.

~Denise
Fast Times @ Homeschool High ( http://fasttimes.clubmom.com ) and Flamingo House Happenings ( http://www.flamingohouse.net</a )

Denise 94 pts moderator

Believe me, I know the facts and was not influenced by any advertising at all. None. In fact I didn't even see any advertising until I took Michelle in for her first injection.

Hpv if caught early usually does not lead to cancer. If caught early. Do you know how many women I talk to everyday who have HPV? (ack an entire sentence disappeared! reading it now) Do you know how many women I talk to everyday who are diagnosed with HPV and then within months come back with abnormal paps and then cervical cancer? You don't want to know.

Both of my older daughters have had the first 2 shots in the series and are counting the days til they can get the third.

We definitely know the facts and the right decision was made.

~Denise
Fast Times @ Homeschool High ( http://fasttimes.clubmom.com ) and Flamingo House Happenings ( http://www.flamingohouse.net</a )

barnyardmama 5 pts

Personally, I'm tired of the government requiring people to do things to their bodies. The number of mandatory vaccines just so kids can stay in public school is ludicrous. What ever happened to letting people makes their own decisions about their health?

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