Radiation For Breast Cancer And Genes In Common Show An Increase in Cardiovascular Disease

Barron’s Medical Journal Reporting from The University of Texas Medical School Houston, Texas

Radiation For Breast Cancer And Genes In Common Show An Increase in Cardiovascular Disease


Houston Texas ( AP )Genetic and genomic testing information will allow early and more accurate prediction and diagnosis of disease and of disease progression. Medicine is now oriented towards disease prevention rather than efforts to cure people at late stages of illness.

Barrons Medical Journal ask CEO Rose Conrad of Sam Houston BiotechIn Houston, Texas to discuss the correlation between breast cancer and heart disease.

Conrad was quick to point out that genomics will allows us all to live longer and her research indicated that people should know that genes “GEE and FBAT “ is common in Cardiovascular disease  and Breast Cancer Patients .

Cardiovascular disease (CVD) is a common cause of morbidity and mortality. While we understand many components of this risk, the ability to provide individualized treatment that maximizes efficacy and minimizes side effects is an elusive goal. Because CVD has high heritability, genomic diagnostic approaches can provide the basis for this by dissecting out the genetically distinct components of this risk.

Breast cancer is the most common cancer in women -- more than a million cases are diagnosed each year worldwide. When it's confined to the breast, most women get surgery to remove the lump, followed by several weeks of radiation to kill any lingering cancer cells and sometimes hormone or chemotherapy.

Age-specific risk estimates are available to help counsel and design screening strategies for women with a family history of breast cancer. Of all women with breast cancer, 5% to 10% may have a germ-line mutation of the genes BRCA1 and BRCA2. Specific mutations of BRCA1 and BRCA2 are more common in women of Jewish ancestry The estimated lifetime risk of developing breast cancer for women with BRCA1 and BRCA2 mutations is 40% to 85%. Carriers with a history of breast cancer have an increased risk of contralateral disease that may be as great as 5% per year. Ma le carriers of BRCA2 mutations are also at increased risk for breast cancer

Conrad pointed out that researchers studied the medical records of 2168 women in Sweden and Denmark who had radiation for breast cancer between 1958 and 2001. They

estimated that the heart was exposed to, on average, a total of 4.9 units of radiation—called grays—during radiation of the breast. The rate of major heart events was found to increase slightly with each gray. Major heart events included heart attack, the need to unblock or replace blood vessels to the heart, or death from a reduced blood supply to the heart (ischemic heart disease). For women who already had risk factors for heart disease, the risk of a major heart event increased a little more. But overall the increased risk was still very small.

For example, for a 50-year-old woman with no pre-existing heart risk factors, a 3-gray dose of radiation would increase her risk of having a major heart event before age 80 by 0.9% (from 4.5% to 5.4%). If she had one or more pre-existing heart risk factors, a 3-gray dose of radiation would increase her risk of having a major heart event before age 80 by 1.7%.

Radiation Treatments: Women treated with radiation for breast cancer are more likely to develop heart problems later in life, even with the lower doses used today, a troubling new study suggests. The risk comes from any amount of radiation, starts five years after treatment and lasts for decades. Some chemotherapy drugs are known to harm the heart muscle, but the new study shows radiation can hurt arteries, making them prone to harden and clog and cause a heart attack. Women who receive both treatments have both types of risk.

Fitness can help, studies found few prospective studies have evaluated breast cancer mortality in relation to cardiorespiratory fitness (CRF), an objective marker of physiologic response to physical activity habits. The association between CRF and risk of death from breast cancer in the Aerobics Center Longitudinal Study. Women (N = 14,811), aged 20 to 83 year with no prior breast cancer history. maximal treadmill exercise test duration and was categorized for analysis as low (lowest 20% of exercise duration), moderate (middle 40%), and high (upper 40%). At baseline, all participants were able to complete the exercise test to at least 85% of their age-predicted maximal heart rate. This is a indication that Fitness is important to breast cancer patients. Skin Care for women with breast cancer is a major concern for breast cancer patients and their loves ones. Women that have to under go chemotherapy and radiation therapy skin care have improved over the years. Genomic science allows Researcher and Physicians to look at each breast cancer patient and recommend a treatment strategy to maintain skin management. Lets discus the different types of breast cancer. Breast cancer is a disease that occurs when malignant (cancer) cells form in the tissues of the breast. There are three main types of invasive breast cancer (cancer that has spread beyond the layer of tissue in which it developed and is growing into surrounding, healthy tissues).

Invasive ductal carcinoma: Begins in the ducts that carry breast milk and is the most common type of breast cancer (8 in 10 women with breast cancer have this type) Invasive lobular carcinoma: Begins in the glands that make breast milk and is less common than invasive ductal carcinoma (1 in 10 women with breast cancer have this type) Inflammatory breast cancer: Found in the lymphatic system of the skin of the breast and is an uncommon type of breast cancer (1 percent to 3 percent of all breast cancer diagnoses are inflammatory breast cancer)

In advanced cases, breast cancer cells may spread (metastasize) to other parts of the body via the blood stream or lymph system.

Scientist say breast cancer chemotherapy treatment can cause your skin, hair, and nails to become brittle, dry, and sensitive. Cell turnover is diminished or halted all together during chemo treatments, meaning that the current cells of your skin may not be getting renewed like normal. This means that you need to treat your skin with care. The vitality of your skin, hair, and nails is going through the same struggles as the rest of your body. 1. Moisturizing your skin immediately after washing and toweling dry.

For your body, this means applying moisturizer after the bath or shower.

For your face, this usually means applying moisturizer in the morning and at night.

For your hands, this means moisturizing after washing many times during the day.

For your lips, this means using a hydrating lip balm throughout the day. 2. Cleansing your skin with gentle cleansing products only. Apply them only where you need them and be sure to rinse them off thoroughly with warm water.

For your body, this means you typically only need to soap up the parts of your skin that have the body odor glands (apocrine glands) including your armpits, groin, buttocks, and feet. If you still have oily skin when you are on chemo, you’ll also need to use cleanser on the oily areas of your back, neck, and chest too. For your face, this means using the mildest cleanser that gets off your makeup and products, but that isn’t so harsh as to dry out your skin. Don’t shoot for that tight “squeaky clean” feeling after washing because it means that you removed too much of your natural oils and actually irritated your skin.

For your hands, this means using cleanser only on your palms most of the time. Skin on the back of your hand rarely gets into germs and grime, and it’s fragile and prone to dryness. Also, the space between your fingers and under your rings trap cleanser, so be careful to rinse all the cleanser off well; retained cleanser will irritate and “burn” your skin, worsening some of the hand-skin problems that occur during chemo.